Mcm1Arg80 Ancestral Library

If you use these results in your work, please cite: Hanson-Smith and Johnson, PLoS Comp. Bio., 2016


Overview | Alignments | Sites | Trees | Ancestors | Mutations


Sequence Alignment muscle

Color by: hydrophobicity mass polarity volume

                                                                 
             

 

 
[hide] ABR.ancMcm1
[hide] Calb.ancMcm1
[hide] Cgla.paralog1
[hide] Cgla.paralog1.duplicate
[hide] Cgla.paralog2
[hide] Clus.ancMcm1
[hide] Ecym.ancMcm1
[hide] Klac.ancMcm1
[hide] Kpol.paralog1
[hide] Kpol.paralog1.duplicate
[hide] Kpol.paralog2
[hide] Kthe.ancMcm1
[hide] Kwal.ancMcm1
[hide] Lelo.ancMcm1
[hide] Lklu.ancMcm1
[hide] Ncas.Paralog2
[hide] Ncas.paralog1
[hide] Ncas.paralog1.duplicate
[hide] Ndar.paralog1
[hide] Ndar.paralog1.duplicate
[hide] Ndar.paralog2
[hide] Sbay.Paralog2
[hide] Sbay.paralog1
[hide] Scer.Paralog1
[hide] Scer.Paralog2
[hide] Tdel.paralog1
[hide] Tdel.paralog2
[hide] Tpha.paralog1
[hide] Tpha.paralog1.duplicate
[hide] Tpha.paralog2
[hide] Xafr.paralog1
[hide] Xafr.paralog1.duplicate
[hide] Xafr.paralog2
[hide] Xbla.paralog1
[hide] Xbla.paralog1.duplicate
[hide] Xnag.paralog1
[hide] Xnag.paralog2
[hide] Ylip.ancMcm1
[hide] Zrou.paralog1
[hide] Zrou.paralog2

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--------------------------------------------------------------------------------------MS---------------DAEKA-----------------------------------------EQPQQKERRKIEIKFIQDKTRRHITFSKRKHGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKFQPIVTQPEGKNLIQACLNAPEEEEEDEDEDEDEVKD--EDKPD-------------------------VSVGGVAGPNAVQDVPGNP----GPVDVGVPA---------------------------------------------DHVAAAHSVAA-----------------------ATAHHHA--------------------------------------------VAAHHHQLSPQQQQNFNNPA-----AYLNAEQAAVNQQYF------NGVNSQQGQY
----------------------------------------------------------MAIKEETNEFSQGNEGNSHSTNNNNNSNNS---------------NSNNNADVSAPVDDDD----DDDGTSQ-------------------GKTQ-KERRKIEIKFIQEKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKLQPLVTKSEGKNLIQACLNAPEEGLGDDQENQSDGNT--GDSPD-----------------------------QSPAPATNPNVMGAA----GHAHHI------------------------------------------------QQQQQQQQQAQ-----------------------QQAQQQMAPMPSHGL---------------------------PTHYSN---PQGAGNPGVPPQQQGQHQPGIPLQGGYSDQY------SYFGNIQNNNIPNQQQYQ-
----------------------------------------------------------MSDKEDINGNNMEDKVDDIDDDGSMTGSVS---------------GSNSVLNEMSAEPKSN----NGTSFEN-------------------TSTP-KDRRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLIVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDEDGEEDDEEEQDEDH--GDTQN---------------------------GNPDLGSNSQTDLPHHL----RQNAVHNQMLDNQQQL--------------------------------------QNQNLLQQPQH-----------------------SNQTLDHQALPQNHN-----------------------------PYPN---IAMGDMGQQYMKGQDHQDPT---------------YQQYF--------QDTS----
--------------------------------------------------------------------------------------MS---------------DIDED------------------TSTP-------------------TGGQ-RERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDD---DEEEEEEEFDTSMQQGQQ------------------PQNQHQEQIAEQNKQPHTQKNNAPMD----------------------------------------------------------QQHMQVHQEQV-----------------------AYSHDDKGHVPEMNG---------------------------QGGAPG---FANGQDMHLQQQGKGPNQYN-----HYLNEEQNSVYQQYF--------QDQQAHYG
------------------MNSQSLFGISPISSSDHINLDPDLGKMPGMPGMPGIQGQRQDQRPQRQVQMPAHMPGQRPTVGGGDEVRGTRDYSDKGNGNGNEHEIENEQENENENENDD----EDEEVST-------------------PSSAVGKRRKAPLKYIENTTRRHVTFAKRRHGIMKKAYELAVMTGANVLLLILS-PKGLVYTFATPSLQPLIRDDPGKELIRRCLNQDNST-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------MSEVTDSAKLESNEDVMGAP---------------GAQFSRGSVSGVGGDD----DEDDEPS-------------------GGKQQKERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKLQPLVTKSEGKNLIQACLNAPEEGLGDDQGDQSDGNS--QDSPD------------------------------QSPAQPQPQAVPHP----QVPAQH------------------------------------------------QHQAAAHQQQQ-----------------------QQQQLPPAHMPH------------------------------GMPYQG---QGHPQGGLPMPQAGGYNDPY-----------------QFFGNMPNGNMPNPQQYQ-
--------------------------------------------------------------------------------------MS---------------DTEKQ-----------------------------------------DQPQQKERRKIEIKFIQDKTRRHITFSKRKHGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKFQPIVTQPEGKNLIQACLNAPEEEEEDEDEEDDDEEIKDEDKPD-------------------------VSVGGVAGPNAVQDASGNPNAVNVGVPSN------------------------------------------------DHVAAAHSVAA--------------------GAAAHHHHHHHHHAAAAA------------------------------------VAAHHQQLPPQQQQNFNNPA-----AYLNAEQAAVYQQYF------NGVNSQQGQY
--------------------------------------------------------------------------------------MS---------------DSEVK--------DDS----V-------------------------TKET-KERRKIEIKFIQDKTRRHITFSKRKHGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKFQPIVTQPEGKNLIQACLNAPEEDDEDDDDEEEDEDE--DDEHN-----------------------VQHDHGGDVGGQPHSTVPTSV----QLPGGGHSHGLLPQQ---------------------------------------QQQQQQQQQQQ-----------------------QQQQQQQRLALQQQG---------------------------QNSQQQ---QQPQSVQHQQPQVQGTGQTPNFTNASYLNPDHAAAYEQYF------NGVNSQHGQF
--------------------------------------------------------------------------------------MS---------------DVDDI--------DDS----TGNG----------------------SGVQQKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDE---EEEEENDDQQQ--PQQGQ----------------QQQQQQQQQQVQQQGQQGQQQVQQGQQS----NGVLGDSQQDMKQDL---------------------------------------KHHVMTNNNLI-----------------------PQAGINQAAMNSIPN------------------------------QNI---AQHQGISLQHPNPQNYQNPS----QSFLNQDQNAVYQQYF--------QETQQGQY
--------------------------------------------------------------------------------------MG---------------DSNDS--------GDE----NTTVNSN-------------------DGST-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDE---EEEEEENDHQH--INASNTNNNNSDNISTNNNENVNSNPNNAGSLIQQQGHLQSNQLIPNIK----QDNDIDSRNIPNNGQYNH------------------------------------NQMVNPHMQPN-----------------------LQSQQNGPNSGLIPT---------------------------QGMQPQ---PQHGNTINVPPNVQASYNAS----PSYFNNEQNAVYQQYF--------QESHQGQY
--------------------------------------------------------------------------------------MV---------------KVESTEAHLENGARPY----PTYIDDP-------------------EDEPNGKKRKLQLKYISNKSRRQVTFSKRRIGLMKKCYELSVMTGVNMLLLVASTDSKLVYTFSTPKLRRFIEENEGKSLVRNCLKKEDS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------MS---------------DTGVD--------DKE----LSAGPQP-------------------QPQQ-KERRKIEIKFIQDKTRRHITFSKRKHGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKFQPIVTQPEGKNLIQACLNAPEE---DEDAEEEEDDD--EDADD---------------DD-----------------DAAKLPSAHQ----QVPMAG-----APPQ---------------------------------------QHGQQPHQQQQ-----------------------QQVQQHAHAHAHAHA---------------------------QQHPHQ---QQQQQQPPQAAAAAAYGNPA----AAYLSADQAAVYQQYF------NGVNPQQGQY
--------------------------------------------------------------------------------------MS---------------DTGAD--------EKE----LSVGAQS-------------------QPQQ-KERRKIEIKFIQDKTRRHITFSKRKHGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKFQPIVTQPEGKNLSRRVSTR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------MSLKGEDGPEYENSANGN---------------PISSSLSNPPMDDDDD----DESGAAS-------------------SGKTQKERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKLQPLVTKPEGKNLIQACLNAPEEGLNDDAGEQSDGAE--GESPE---------------PNAVSSSTQQQQQQQQQAPQALAQPPHLP----HHVQHQAQQQAQQQHAQLQHQQ--------------------------------QQAAAAAAAAA-----------------------HQGQVHQQQYPPQPQ---------------------------TQAYPG---QQPQQPAPPGHPQQQPPQQQGAVQGGAPGGQPGVSYGDYYFGNMQNNNIPNQQQYQ
------------------------------------------------------------------------------------MSNT---------------PTEEK---------------PGAGTSQ-------------------QPQQ-KERRKIEIKFIQDKTRRHITFSKRKHGIMKKAYELSVLTGTQVLLLIVS-ETGLVYTYTTPKFQPIVKEPEGRNLIQACLNAPDEEEEEEEEDDDEEEEAKNEDKP--------------------------ADVTTAAAAAAGGVAADP----------------------------------------------------------STGAIPHPQAG-----------------------NPV------------------------------------------------VQNPQGASVQQQPQSFGNPA-----AYLNAEQAAVYQQYF------NGVNSQQGQY
------------------MEINQLTRGSKVKIVEQNESDRRIAEAPKVPGKIAATTQAVSDDEGDLECGEDEDDEEEEDTLNLNREEL---------------AIDVGEDDEEEEEGDE----EEDLELEEETTPSLRNTPTGDASDQLGGSPDSMRQRIPIKYIENKTRRHVTFAKRRHGIMKKAYELSVLTGANVLLLILS-GSGLVYTFSTPKLEPVIRDEEGKGLIRACLNGPDG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSAAIFYPPNELE-----------------------------------------
--------------------------------------------------------------------------------------MS---------------EEQNIE-------KDD----SIVADSP-------------------ASNQ-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLIVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDE---DEEEEEEGDEE--EDVDD----------------AGENNNRGGSVDNINIDPRNHDNMVNVQ----NNNNVNI-----------------------------------------------DQSNLISQAYH-----------------------PNQIQSQIQQLGLPN---------------------------PVTDLF---NLPTNDQSFQNQKVAYGKVE---------DVPNGKYAQYF----------EQQNQV
--------------------------------------------------------------------------------------MS---------------DTESGVQDQIIINNQE----AESSSTS-------------------TADP-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDD---EDEEEEDEDGE--GDDNN-------VQTNINDENDEINNNNNNNNNNTNSNMTSHNNIHNNI----NGVPNNAENLVPVTTDIHQENNMNLNGINSMNALNSMNQAIANVGVHSSILNNNNNNNSPLNQSEIKTEMKPTVTLENNQVISSAGTFPNQYQHPQQHPQQQH---------------------------GQQQQQ---QQQNALVQQFQNAQNFTNVG----SPYLNSEQSAVYQQYF--------QESQQNQF
--------------------------------------------------------------------------------------MS---------------DTNSK------------------TPIE-------------------EPST-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNVPDE---EEEEEEDEDPE--NEGTN--------------------------------GMDTRSGIISPD----TDNIH-------------------------------------------------PDANVTYSNEA-----------------------PQAHLD------------------------------------PETYSV---PANQQPQFHDNRSNDVNNQN--------------TYRYYQ-----ESQQHHQQPPF
--------------------------------------------------------------------------------------MS---------------DVEN----------------TPEGSQQ-------------------SGST-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDE---EEEEEEEEGEE--EDNNDHITNQGAEILGSSITEQDPSARHNSTSSMTNIGMDSMNAINSMK----QAIAGSTNAMVPPGQLPLQMQQVGMKREGNSNNMTIGQTSVVSSSGTLGNQFSTQNQQQLQPTTQ-----------------------QQQQEQQQQHIQQQR---------------------------QQQQQQ---QGNPATSHHYQHGQGFPNTN----SPYLNAEQNAVYQQYF--------DEQQQNQF
MVVKKRGLNEDERNDNEYDQSKKMKIVDTISKEQIGTATATATTTTKSVTNAVSFVNQNEPVEGENEEDDYEDEDEEDISLNKEELSGNLGGLDEGEGGGKEEDEEEEDEDEEDVAIDSESYRESSASVPATSVDKVTLTNARTPSVPESPRSSSSKQKIPISFIENKSRRHVTFAKRRHGIMKKAYELSVLTGANVLLLILS-SSGLVYTFTTPKLEPVIRDDEGKNLIRKCLGAPDNWEYDEGTRANPES-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------MAWNGNGSDIRVLEEPTVGNIAAIDSNGSVRRPPSQLMQDEQ---------------DDDEEDDDEDKSSVEP----STPTPTT-------TKTKENTSTILTTTSTTTARQKQPIKYIENKTRRHVTFSKRRHGIMKKAYELSVLTGANILLLILA-NSGLVYTFTTPKLEPLVREDEGKNLIKACINAPDA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PPTHDQPATN--------------------------------------
--------------------------------------------------------------------------------------MS---------------DIEEG------------------TPTN-------------------NGQQ-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEEDDEEDGDDDDE--EDDDD---------------GNDMQRQQQQQQQQQQPQQQQQQVLNAHA----NSLGHMNQDQVPPGALKQEVKSQLL-GANPNQTPIIQQQHHAQNPQ--------TQQPQQQQQQQ-----------------------QQQQQQQQQQPQMPQHPQPQQGIPHPQQS-------------QQQQQQ---PQQPLTGIHQPHQQAFANAG----SPYLNAEQNAAYQQYF--------QEPQQGQY
--------------------------------------------------------------------------------------MS---------------DIEEG------------------TPTN-------------------NGQQ-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDEEEDEEEDGDDDDDDDDDGND----------------------MQRQQPQQQQPQQQQQVLNAHA----NSLGHLNQDQVPAGALKQEVKSQLLGGANPNQNSMIQQ----------------QQHHTQNSQPQ-----------------------QQQQQQPQQQMSQQQMSQHPRPQQGIPHPQQSQPQQQQQQQQQLQQQQQQQQQQPLTGIHQPHQQAFANAA----SPYLNAEQNAAYQQYF--------QEPQQGQY
--------------------------------------------------MTSNSDGSSTSPVEKPITGDVETNEPTKPIRRLSTPSP---------------EQDQEGDFDEEDDDDK----FSVSTST--------PTPTITKTKDSSDTSTVTRRKQPIRYIENKTRRHVTFSKRRHGIMKKAYELSVLTGANILLLILA-NSGLVYTFTTPKLEPVVREDEGKSLIRACINASDT------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PDATDTSPAQEQSPAN--------------------------------------
--------------------------------------------------------------------------------------MS---------------DIEDV----------------EDTGSR-------------------TGQP-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDDEEEEEEEDEDARE--GAEEN-------------------DSSNQVSSSEQQQQIQQQQQIQQQQ----QQIQQQQQQQIQQQN---------------------------------------QPQQLLNNPLK-----------------------QEGIKNHSMHPAMNPGHGIPAGVPSAPM--------------GMPQQN---PHQPHPGMPHPHLQGFPNSA----SPYLNPEQNAVYQQYF--------QESQQGQY
------------------------------------------------------MCKGHQLFFFHFTRCKAHRMEQSQEQENKKMGHN---------------EMMRAQDEDPSTMDQS----NSATPVS-------------------IEGK-GAKQKVPVKYIANPARRHVTFAKRRHGIMKKAYELSVLTGANVLLLILS-KSGLVYTFTTPKLERIVREQEGKRLIRQCLQEETM----------------GETT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------MEEPIAKPKVGETIVADS---------------AIDDDASH-----LED----DEDATGK-------------------KNGQ-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDE---EEELEQEMEHD--NDAEA------------------------------GAPGPAVQQMQAPQ----QQVQQQ------------------------------------------------QAQQQPHKAAA------------------LLGVKEDIAGQHHGRLPIPQ---------------------------EQYQAQ---QLSQQRQQQQLQQQGPRQGQ------YLNQDQNAVYQQYF--------QENQQNHY
--------------------------------------------------------------------------------------MS---------------DSEDHKLDLKTDSKDS----SLLSPSS-------------------TGSTAKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDE---EEEEEEETNKH--ENGNN---------AGSLIQQQQQQQQQQQLQQDQQQKQQQSPQMQQQP----PQLQQHQQHPPPPQQQ--------------------------------------HSGILNNNNSA-----------------------NYMSVQQIQQPLKQV---------------------------PFSNVN---IQPPIPNNQYYQAQNPTQQQ---------QQQNSVYQQYF--------QETQQTNY
-------------------------------------------------------------------------------------------------------MTDHK----------------------------------------------TKNKKIKIDFIVNKTKRRLTYNTRRVGLMKKSYELSLITGVNILLLISSINDDYVYFFSSPKLRNFVNCNEGQKLIRKCLQEES-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PKAIETKKHHLEMCRFCNWR------------------------------FKIRNH
--------------------------------------------------------------------------------------MS---------------DQDIKESQTSHIEEDP----SLSPSTN-------------------NG---KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDE---EEEEEDDQQVQ--QQQQQ-----------------------------------VQQQVQNDA----VAQAQA------------------------------------------------QAQAHAHAQQV-----------------------QQMQQQVQQHQLQQH---------------------------PFTIDG---FANPKVNTQQLPQQQDTKPT----------ANNAAYQQYF--------QESQQNQF
--------------------------------------------------------------------------------------MS---------------DKEEN---------------NGNTSQD-------------------KVNIIKERKKIDIKYIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQPEGRNLIQACLSAPDQLSDDDEKDGSNLNK--SNFSD------------------------------------SSNLFGKN----EDVKMNI-----------------------------------------------RPNVSSNLTIQ-----------------------QPAQPQRQQYNAQNE------------------------------------QNMAQTGMIPQRQETYTSSN-----PYVA---NAFYPNYY--------PDVSENQY
--------------------------------------------MHIRSGATISDMRNHSDFVAGDLEEENTKEPRRPPRGPSMNTTS---------------NSNNNNVNKDSLVEGT----NNETSIP--------SPEDSVEEEEEDYDLKRARRKNPIKYIENKTRRQVTFAKRRHGLMKKAYELSVMTGANILLLIVS-NTGLVYTFTTPKLEPVVINEEGKNLIRACLNAEDN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------MSDIDDTTDANQQLSATSPHNANSVTTDSTDNQVSSTITNSNSAVT---------------DPTSDSVNTPGNQDVV----ATAGNST-------AGNSVDTPGSGSATDGPKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDD---DDDDDGNNNND--GEQQNVIQANEQAQMGQITNGMTQQQQLATLQQQQQQQQQPQQQQMQHPAMGMNPQQGQQGQQGQIPTSVGEHLQNQLQKTADNGIKQELQKPMDQNQMVGIIPNHNQNVQVQNAQGNPHLIPLQNGAAMQQHMAQQQGNPMQQQPQQQQQPQQPIGGMMTNEQLHAQQQAQAQHAQAQQAQAQQQSHQQMMQGHPEMQGNPNQQQNFQNLA----NQYLSSDQNAVYQQYF--------QESQQGQY
-------------------------------------------------------------------MSDIEDNTESSTHTDQLNGTP---------------NSSTNTDPNSSTTLTN----NPSAASA-------------------ALNAQRERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDD---DDDTNAAASGDMGPEDSKQPQQLTNGQPDNAMMKNEYDQTNQQIPQQQQQQQQQQQQQQQIP----QQIPQQIPQQLPQNQIRNQNIPQQSQNSAANA----------------------LSQQQMYQQQQ-----------------------QQQQQQQSQMQMQPGSNLP-----------------------PHLQQQ---QQQPLPPMNQQQQHPQHPQQ----YSYLNPEQNSVYQQYF--------QESSQGQY
---------------------------------------------------------------------------MSDQELKEDPTLS---------------PANSAGNNVGGDPDTP----TGSGSGG-------------------NGASQKERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDD---DDEEEEEADDE--EAQRQ--------------------QQQQVQKQQQVQQQGQQQAMHAQQ----QQQLQQQHQQMQMQQVPQ------------------------------------QMGQPPHLHQL-----------------------PPVAGDHPHAFSMDGFGNGKDGQGVPMGGPGNPGTGSIQQQ-GIPQQQ---QQGIPAPQQQQQQQQPHDQIKMDPHGSASGATNAVYQQYF--------QTAQPNQY
----------------------------------------------MKGALRDVPSKKTTSKVETRSVTRGRSTKGVDSAGSNNSDAS---------------DEEEEDEEEDDEDEDD----DAQEDED--------LDEEDDHDLDLMEEPRDVRRKVPIKYLENRTRRQVTFAKRRHGIMKKAYELSVLTGSNILLLILS-RSGLVYTFSTPKLEPIIRDEEGKTLIRKCLNAGEA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GPW
----------------------------------------------------------------------MSDEGLADPSLGDSLQQS---------------DNVLKRESSQGGPGDV----GSDDDDA-------------------GGKLGRERRKIEIKFIQDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVS-ETGLVYTFTTPKLQPLVTKPEGKNLIQACLNASDDVPVAAAESQDARQQ--QQQHQ--------------------QRHGSHVNSQANGPGGSQVAGGEL----PDQLVEDQLGGHPGL---------------------------------------ARGPPPNMGGM-----------------------QPGMNY-----NMNQ---------------------------DSAAQA---YQHYLSMPQQQQQQQQQQQQ-----RYMAAQPGHM---------------PHQAHQ
--------------------------------------------------------------------------------------MS---------------DIDDV--------ED--------NSSR-------------------AGQQ-KERRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLVVS-ETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDDDEDDDEEEEEAPEDPNGAAAA----------------------------------AAAAQMAGQP----THVPNTAGLGPHPHELHA------------------------------------AGGLKPDPMKA-----------------------AHAMQGHEGAPTMPI---------------------------PTQHTA---HQPHPVMPPPPHQQGFANTA----SPYLNPEQNAVYQQYF--------QESQQGHY
--------------------------------------------------------------------------------------M----------------DEERNRTPASVDTQEP----DDDEDEE-------------------ERNSSQQKRKYPIKYIENRTRRHVTFAKRRHGIMKKAYELSVLTGANVLLLILS-NNGLVYTFTTPKLEPVVREREGKELVWKCLDGRPTP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

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